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Mauna Kea Technologies Announces Publication of a Landmark Systematic Review and Meta-Analysis Reinforcing the Diagnostic Accuracy and Clinical Impact of Cellvizio in Upper Gastrointestinal Cancer

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Largest ever meta-analysis of upper gastrointestinal endomicroscopy pooling 33 studies and 2,350 patients

Original research conducted and funded by Korea's National Evidence-Based Healthcare Collaborating Agency (NECA)

Authors document major clinical impact in the early diagnosis of esophageal and gastric cancers: dysplasia detected in nearly three times as many patients in Barrett's esophagus surveillance, with 48.5% fewer biopsies per patient

Endomicroscopy characterized as safe and accurate adjunct to standard upper gastrointestinal endoscopy

Systematic reviews with meta-analyses are among the strongest clinical evidence used by guideline committees and payers

PARIS & BOSTON, August 26, 2026--Regulatory News:

Mauna Kea Technologies (Euronext Growth: ALMKT), inventor of Cellvizio®, the multidisciplinary probe and needle-based confocal laser endomicroscopy (p/nCLE) platform, today announces the publication of a landmark independent systematic review and meta-analysis of probe-based confocal laser endomicroscopy (pCLE) in upper gastrointestinal cancer, conducted and funded by Korea's national health technology assessment agency.

Published as an original research article in Endoscopy International Open1, the meta-analysis pools data from 33 studies involving 2,350 patients, of which 15 focused on esophageal lesions, 16 on gastric lesions and two covering both sites.

The study was conducted and funded by the Division of Health Technology Assessment Research of Korea's National Evidence-Based Healthcare Collaborating Agency (NECA), the country's national health technology assessment organization. Its protocol was defined in advance by a dedicated evaluation committee assembled by the agency, comprising pathologists, gastroenterologists, methodological experts and biostatisticians, and the work followed Cochrane and PRISMA methodology, with QUADAS-2 quality assessment, bivariate random-effects modelling of pooled diagnostic accuracy, pre-specified sensitivity analyses and formal testing for publication bias.

Co-authors are affiliated with NECA, CHA University School of Medicine, Asan Medical Center (University of Ulsan College of Medicine), Yonsei University College of Medicine and Seoul St. Mary's Hospital (The Catholic University of Korea College of Medicine). The authors declare no conflicts of interest. Mauna Kea Technologies played no role in the design, conduct, funding, or interpretation of the review.

Enhanced lesion detection and reduced biopsy burden

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