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Delcath Systems Highlights Clinical Program Presentations at ESMO Congress 2026 and Independent Data on Percutaneous Hepatic Perfusion in Liver-Dominant Metastatic Uveal Melanoma

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QUEENSBURY, N.Y., October 19, 2026--Delcath Systems, Inc. (Nasdaq: DCTH), an interventional oncology company focused on the treatment of primary and metastatic cancers of the liver, today announced presentations related to its clinical development programs at the European Society for Medical Oncology (ESMO) Congress 2026, taking place October 23–27 in Madrid, Spain. The Company also highlighted the publication of an independent, investigator-led analysis of percutaneous hepatic perfusion (PHP) with melphalan using the CHEMOSAT® Hepatic Delivery System in patients with liver-dominant metastatic uveal melanoma (mUM).

ESMO Congress 2026 Presentation Details

Company Sponsored Trial-in-Progress Poster Presentation
Title: DELUMA: An Open-Label, Randomized Phase II Study of Melphalan/HDS Induction Followed by Standard Therapy vs Standard Therapy Alone in Patients with Liver-Dominant Metastatic Breast Cancer
Abstract Number: 58TiP
Presenter: Heather McArthur, MD, MPH; UT Southwestern Medical Center, Global Principal Investigator
Date/Time: Saturday, October 24, 2026, 12:00 CEST
Location: Poster Area, Hall 5, IFEMA Madrid

"Meet the Investigators" Session
Date/Time: Saturday, October 24, 2026, 16:30–17:00 CEST
Location: Valencia Auditorium

  • Del-Liver Phase 2 trial in metastatic colorectal cancer – update presented by Global Principal Investigator Marwan Fakih, MD, City of Hope

  • Deluma Phase 2 trial in metastatic breast cancer – update presented by Global Principal Investigator Heather McArthur, MD, MPH, UT Southwestern Medical Center

The session will conclude with an open Q&A discussion.

Poster Presentation – Independent Investigator
Title: Liver-metastatic uveal melanoma comparison: melphalan hepatic delivery (PHP) + ipilimumab/nivolumab versus tebentafusp
Abstract Number: 2135P
Presenter: Cato Boreel, Dutch Institute for Clinical Auditing (Dutch Melanoma Treatment Registry)
Session Type: Poster
Date/Time: Saturday, October 24, 2026, 12:00 CEST
Location: Poster Area, Hall 5, IFEMA Madrid
Summary: Compares regional treatment (melphalan hepatic delivery/PHP) plus ipilimumab/nivolumab with systemic tebentafusp in patients with liver-metastatic uveal melanoma.

Independent Analysis of CHEMOSAT PHP in Liver-Dominant Metastatic Uveal Melanoma

Independent investigators from St Vincent's University Hospital in Dublin, Ireland published a retrospective analysis of patients with liver-dominant mUM who were referred to University Hospital Southampton for chemosaturation with percutaneous hepatic perfusion (CS-PHP) between 2019 and 2026. The abstract, "Outcomes and safety of chemosaturation with percutaneous hepatic perfusion (CS-PHP) in liver-dominant metastatic uveal melanoma: Impact of molecular profiling on survival" (Abstract 119P), appears in ESMO Open, Volume 11, Supplement 7 (September 2026), and is available here.

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